SIRT1 Inhibitor, EX-527
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Catalog number1652-10
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Price:
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Size10 mg
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Alternative_nameEX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
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DescriptionA potent SIRT1 inhibitor (IC₅₀ = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.
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CAS Number49843-98-3
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₃H₁₃ClN₂O
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Molecular Weight248.71
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Cell PermeableYes
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Purity≥97% by HPLC
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SolubilitiesDMSO (20 mg/ml)
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HandlingProtect from air and light
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Tag LineA SIRT1 inhibitor
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Storage Condition+4°C
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Shipping ConditionRT
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Shelf Life24 months
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MDL NumberMFCD03009471
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PubChem CID5113032
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SMILESC1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
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InChiInChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
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InChi KeyFUZYTVDVLBBXDL-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolSIRT1-AS, SIRT1, MIR527
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Short nameSIRT1 Inhibitor, EX-527
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Alternative namesirtuin 1 suppressor, EX-527
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Alternative to gene targetsirtuin 1, SIR2L1, SIRT1 and IDBG-75847 and ENSG00000096717 and 23411, keratin filament binding, nuclei, Sirt1 and IDBG-159441 and ENSMUSG00000020063 and 93759, SIRT1 and IDBG-629119 and ENSBTAG00000014023 and 613629
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Gene info
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Identity
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Gene
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Long gene nameSIRT1 antisense RNA
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Locus
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Discovery year2015-09-23
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Entrez gene record
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Pubmed identfication
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene namesirtuin 1
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Synonyms gene name
- sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1
- sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-03-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- eNoSC complex
- Sirtuins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 527
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Synonyms gene
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Synonyms
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Locus
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Discovery year2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR515 family