ATR Antibody

• Catalog number
  3767-100
• Price
  Please ask
• Size
  100 µl

• Antibody Target
  ATR
• Target Alternative Name
  ATR, Ataxia telangiectasia and Rad3 related; FRAP, FRP1, FRAP-related protein 1; SCKL, SCKL1, Seckel syndrome
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse
• Immunogen Sequence
  Synthetic peptide of human ATR
• Accession
  Q13535
• Gene Id
  545
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
• Purification
  Affinity purified
• Application
  Western blot
• Application And Usages
  Western blotting (1:1000 – 1:2000). HeLa cell lysate can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the ATR of human and mouse origins. Reactivity to other species has not been tested.
• Description
  ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ATR  
• Gene symbol
  ANTXR1, SERPINA2, ATR
• Short name
  ATR Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  ataxia telangiectasia and Rad3 related (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  ataxia telangiectasia and Rad3 related, FCTCS and FRP1 and MEC1 and SCKL and SCKL1, ATR and IDBG-59521 and ENSG00000175054 and 545, transferase activity, nuclei, Atr and IDBG-191646 and ENSMUSG00000032409 and 245000, ATR and IDBG-638174 and ENSBTAG00000011529 and 504869

Gene info

• Identity
  HGNC:21014
• Gene
  ANTXR1
• Long gene name
  ANTXR cell adhesion molecule 1
• Synonyms gene name
  • anthrax toxin receptor 1
• Synonyms
  • TEM8
  • FLJ21776
  • FLJ10601
  • ATR
• Synonyms name
  • anthrax toxin receptor
  • tumor endothelial marker 8 precursor
• GenBank acession
  • AF421380
• Locus
  2p13.3
• Discovery year
  2003-08-27
• Entrez gene record
  84168
• Pubmed identfication
  • 10947988
  • 11559528
• RefSeq identity
  • NM_032208
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000129575

Gene info

• Identity
  HGNC:8985
• Gene
  SERPINA2
• Long gene name
  serpin family A member 2 (gene/pseudogene)
• Synonyms gene
  • PIL
  • SERPINA2P
• Synonyms gene name
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2, pseudogene
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
• Synonyms
  • ATR
  • ARGS
• Synonyms name
  • protease inhibitor 1 (alpha-1-antitrypsin)-like
  • alpha-1 antitrypsin-related protein
• GenBank acession
  • JX680599
• Locus
  14q32.13
• Discovery year
  2001-06-22
• Entrez gene record
  390502
• Pubmed identfication
  • 15014966
  • 23826168
  • 24172014
• RefSeq identity
  • NM_006220
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000171347

Gene info

• Identity
  HGNC:882
• Gene
  ATR
• Long gene name
  ATR serine/threonine kinase
• Synonyms gene name
  • ataxia telangiectasia and Rad3 related
• Synonyms
  • FRP1
  • SCKL
  • SCKL1
  • MEC1
• Synonyms name
  • MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae)
• GenBank acession
  • U76308
• Locus
  3q23
• Discovery year
  1998-04-06
• Entrez gene record
  545
• Pubmed identfication
  • 8978690
  • 8610130
• RefSeq identity
  • NM_001184
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000159234
• Locus Specific Databases
  • LRG_1403

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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