Human Recombinant AKR1C4

• Catalog number
  6338-100
• Price
  Please ask
• Size
  100 ug

• Synonyms
  Human Recombinant AKR1C4
• Alternative_names
  Aldo-keto reductase family 1, member C 4, DHEA-ST, DHEAS, HST, hSTa, ST2, ST2A1, ST2A3.
• Description
  Involved in in the detoxification of aldehydes and ketones
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Biological activity
  Specific activity is approximately < 0.6 units/mg.
• Unit Definition
  Specific activity is approximately < 0.6 units/mg. Enzymatic activity was confirmed by measuring the amount of enzyme catalyzing the oxidation of 1 micromole NADPH per minute at 25°C. Specific activity was expressed as units/mg protein.
• Molecular Weight
  39.2 kDa
• Storage Temp
  -20°C
• Shipping
  gel pack
• Shelf Life
  12 months
• Concentration
  1 mg/ml
• Appearance
  Liquid
• Physical form description
  1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1 M NaCl and 1 mM DTT.
• Background Information
  AKR1C4 is a member of the aldo/keto reductase superfamily that has over 40 known enzymes and proteins. AKR1C4 enables the conversion of aldehydes and ketones to their corresponding alcohols by using NADH and/or NADPH as cofactors. AKR1C4 takes part in the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver.
• Amino acid sequence
  MGSSHHHHHH SSGLVPRGSH MDPKYQRVEL NDGHFMPVLG FGTYAPPEVP RNRAVEVTKL AIEAGFRHID SAYLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCTFF QPQMVQPALE SSLKKLQLDY VDLYLLHFPM ALKPGETPLP KDENGKVIFD TVDLSATWEV MEKCKDAGLA KSIGVSNFNC RQLEMILNKP GLKYKPVCNQ VECHPYLNQS KLLDFCKSKD IVLVAHSALG TQRHKLWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIREN IQVFEFQLTS EDMKVLDGLN RNYRYVVMDF LMDHPDYPFS DEY
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  AKR1C4  
• Gene symbol
  AKR1C4
• Short name
  Recombinant AKR1C4
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  H. sapiens Rec. AKR1C4
• Alternative technique
  rec

Gene info

• Identity
  HGNC:387
• Gene
  AKR1C4
• Long gene name
  aldo-keto reductase family 1 member C4
• Synonyms gene
  • CHDR
• Synonyms gene name
  • aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
• Synonyms
  • DD4
  • HAKRA
  • C11
  • 3-alpha-HSD
  • CDR
  • MGC22581
• Synonyms name
  • chlordecone reductase
  • 3-alpha hydroxysteroid dehydrogenase, type I
  • dihydrodiol dehydrogenase 4
• GenBank acession
  • M33375
• Locus
  10p15.1
• Discovery year
  1993-08-26
• Entrez gene record
  1109
• Pubmed identfication
  • 7789999
• RefSeq identity
  • NM_001818
• Classification
  • Aldo-keto reductases
• VEGA ID
  OTTHUMG00000017591

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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