Recombinant Rat Podoplanin / PDPN Protein (ECD, Fc Tag)
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Catalog number
PKSR030139-50µg
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Price
Please ask
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Size
50µg
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Synonym
Gp38;Ots8
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Activity
NA
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Sequence
Met1-Leu135
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Fusion tag
C-Fc
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Accession
NP_062231.1
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ExpressedHost
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
> 95 % as determined by SDS-PAGE.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
38.6 kDa
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AP Mol Mass
38.6 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
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About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin name
Rattus norvegicus
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
ECD, PDPN, SEM1
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Short name
Recombinant Podoplanin / PDPN Protein (ECD, Fc Tag)
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Host
Rat
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Label
Fc Tag
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Species
Rat, Rats
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Alternative name
Rec. Rat Podoplanin / podoplanin Protein (ECD, fragment c detection labelled)
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Alternative technique
rec
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Alternative to gene target
podoplanin, AGGRUS and GP36 and Gp38 and GP40 and HT1A-1 and OTS8 and PA2.26 and T1A and T1A-2 and T1A2 and TI1A, PDPN and IDBG-90582 and ENSG00000162493 and 10630, Cell surfaces, Pdpn and IDBG-202630 and ENSMUSG00000028583 and 14726, BOVAGGRUS and IDBG-636063 and ENSBTAG00000001788 and 509732
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Gene info
Gene info
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Identity
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Gene
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Long gene name
podoplanin
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2005-07-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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