AEE-788
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Catalog number9658-1
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Price:
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Size1 mg
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Alternative_name6-[4-[(4-Ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; AEE788, NVP-AEE788
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DescriptionAEE-788 is a potent EGFR and VEGFR inhibitor (IC₅₀ values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC₅₀ values are 52, 60 and 61 nM respectively). Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice.
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CAS Number497839-62-0
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₇H₃₂N₆
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Molecular Weight440.58
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>50 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent EGFR and VEGFR inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID10297043
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SMILESCCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4NC(C)C5=CC=CC=C5
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InChiInChI=1S/C27H32N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-17-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,17,19-20H,3,13-16,18H2,1-2H3,(H2,28,29,30,31)/t20-/m1/s1
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InChi KeyOONFNUWBHFSNBT-HXUWFJFHSA-N
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MSDS AvailableYes
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Gene target
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Short nameAEE-788
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Alternative nameAEE-788
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