AEE-788

• Catalog number
  9658-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  6-[4-[(4-Ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; AEE788, NVP-AEE788
• Description
  AEE-788 is a potent EGFR and VEGFR inhibitor (IC₅₀ values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC₅₀ values are 52, 60 and 61 nM respectively). Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice.
• CAS Number
  497839-62-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₃₂N₆
• Molecular Weight
  440.58
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent EGFR and VEGFR inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  10297043
• PubChem CID Link
• SMILES
  CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4NC(C)C5=CC=CC=C5
• InChi
  InChI=1S/C27H32N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-17-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,17,19-20H,3,13-16,18H2,1-2H3,(H2,28,29,30,31)/t20-/m1/s1
• InChi Key
  OONFNUWBHFSNBT-HXUWFJFHSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AEE-788  
• Short name
  AEE-788
• Alternative name
  AEE-788

Similar products