Human CellExp™ MMP-13, Human Recombinant
-
Catalog numberP1566-10
-
PricePlease ask
-
Size10 µg
-
-
SynonymsCollagenase 3, Matrix metalloproteinase-13, CLG 3, CLG3EC, EC 3.4.24.22
-
Alternative_namesCollagenase 3, Matrix metalloproteinase-13, CLG 3, CLG3EC, EC 3.4.24.22
-
DescriptionA Protein involved in breakdown of extracellular matrix
-
Recombinant1
-
SourceHEK 293 cells
-
Purity by SDS PAGE>95%
-
AssaySDS - PAGE
-
Molecular Weight53 kDa (6xHis tag at the C-terminus)
-
Storage Temp-20°C
-
ShippingGel Pack
-
Shelf Life9 months
-
AppearanceLyophilized protein
-
Physical form descriptionLyophilized
-
Reconstitution InstructionsCentrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
-
Background InformationMMP13 or collagenase 3 is an endopeptidase that is part of the calcium and zinc dependent matrix metalloproteinase family. Like most MMPs, it is secreted as an inactive pro-form and is activated once its pro-domain is cleaved. Additionally, MMP13 is expressed by fibroblasts, chondrocytes, and squamous epithelial cells. MMP-13 (Collagenase-3) has been demonstrated to degrade a range of extracellular matrix proteins, including collagen types I, II, III, IV, IX, X and XIV, gelatin, aggrecan, perlecan and fibronectin. Furthermore, it is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
-
Amino acid sequenceLeu 20 – Cys 471
-
HandlingCentrifuge the vial prior to opening.
-
UsageFor Research Use Only! Not to be used in humans
-
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Additional sourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolMMP13, MMP14, MMP24, PIRC58, MMP28, SNORD114-13, SNORD115-13, IGLV3-13, IGHV3OR16-13, ERVK-13
-
Short nameCellExp™ MMP-13, Recombinant
-
TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
SpeciesHumans
-
Alternative nameH. sapiens CellExp™ MMP-13, H. sapiens Rec.
-
Alternative techniquerec
-
Gene info
-
Identity
-
Gene
-
Long gene namematrix metallopeptidase 13
-
Synonyms gene name
- matrix metalloproteinase 13 (collagenase 3)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1994-11-20
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- M10 matrix metallopeptidases
- Receptor ligands
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namematrix metallopeptidase 14
-
Synonyms gene name
- matrix metalloproteinase 14 (membrane-inserted)
- matrix metallopeptidase 14 (membrane-inserted)
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year1994-11-20
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- M10 matrix metallopeptidases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namematrix metallopeptidase 24
-
Synonyms gene name
- matrix metalloproteinase 24 (membrane-inserted)
- matrix metallopeptidase 24 (membrane-inserted)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1999-08-06
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- M10 matrix metallopeptidases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 58
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namematrix metallopeptidase 28
-
Synonyms gene name
- matrix metalloproteinase 28
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2001-01-09
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- M10 matrix metallopeptidases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 114-13
-
Synonyms
-
Locus
-
Discovery year2006-09-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 115-13
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2007-02-15
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin lambda variable 3-13 (pseudogene)
-
Synonyms gene name
- immunoglobulin lambda variable 3-13
- immunoglobulin lambda variable 3-13 pseudogene
-
GenBank acession
-
Locus
-
Discovery year2000-05-08
-
Entrez gene record
-
RefSeq identity
-
Classification
- Immunoglobulin lambda locus at 22q11.2
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin heavy variable 3/OR16-13 (non-functional)
-
Synonyms gene name
- immunoglobulin heavy variable 3/OR16-13
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2000-04-17
-
Entrez gene record
-
RefSeq identity
-
Classification
- Immunoglobulin heavy (IGH) orphons
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameendogenous retrovirus group K member 13
-
Synonyms gene name
- endogenous retrovirus group K, member 13
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2011-05-05
-
Pubmed identfication
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
