PARP Antibody (Clone 7A10)

• Catalog number
  3023-100
• Price
  Please ask
• Size
  100 µl

• Antibody Target
  PARP
• Target Alternative Name
  PARP, PPOL, ADPRT, ADPRT1, PARP-1, pADPRT-1, PARP1
• Antibody Type
  Monoclonal
• Clone
  7A10
• Species Reactivities
  Human
• Accession
  P09874
• Gene Id
  142
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  1 mg/ml
• Application
  Western blot, Immunocytochemistry
• Positive Control
  Jurkat (1), K562 (2), HeLa (3), Raji (4), THP-1 (5) and SW620 (6) cell lysate.
• Application And Usages
  The antibody performs well on Western blot (1:500-1:2000) and Flow Cytometry studies (1:200-1:400).
• Description
  PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PARP   7A10  
• Gene symbol
  TNKS2, TIPARP, PARP1, PARP12, TNKS
• Short name
  PARP Antibody (Clone 7A10)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Mouse
• Alternative name
  PARP (antibody to-) (clonality 7A10)
• Alternative technique
  antibodies
• Clone name
  7A10

Gene info

• Identity
  HGNC:15677
• Gene
  TNKS2
• Long gene name
  tankyrase 2
• Synonyms gene name
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
• Synonyms
  • TNKL
  • TANK2
  • PARP-5b
  • PARP-5c
  • PARP5B
  • PARP5C
  • pART6
  • ARTD6
• Synonyms name
  • TRF1-interacting ankyrin-related ADP-ribose polymerase 2
• GenBank acession
  • AF342982
• Locus
  10q23.32
• Discovery year
  2001-05-10
• Entrez gene record
  80351
• RefSeq identity
  • NM_025235
• Classification
  • Poly(ADP-ribose) polymerases
  • Sterile alpha motif domain containing
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000018747

Gene info

• Identity
  HGNC:23696
• Gene
  TIPARP
• Long gene name
  TCDD inducible poly(ADP-ribose) polymerase
• Synonyms gene name
  • TCDD-inducible poly(ADP-ribose) polymerase
• Synonyms
  • DKFZP434J214
  • DKFZp686N0351
  • DDF1
  • PARP7
  • PARP-7
  • PARP-1
  • pART14
  • RM1
  • ARTD14
• GenBank acession
  • BX537965
• Locus
  3q25.31
• Discovery year
  2003-12-02
• Entrez gene record
  25976
• Pubmed identfication
  • 12851707
• RefSeq identity
  • NM_015508
• Classification
  • Poly(ADP-ribose) polymerases
• VEGA ID
  OTTHUMG00000158646

Gene info

• Identity
  HGNC:270
• Gene
  PARP1
• Long gene name
  poly(ADP-ribose) polymerase 1
• Synonyms gene
  • PPOL
  • ADPRT
• Synonyms gene name
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
  • poly (ADP-ribose) polymerase family, member 1
• Synonyms
  • PARP
  • ARTD1
• GenBank acession
  • BC037545
• Locus
  1q42.12
• Discovery year
  1986-01-01
• Entrez gene record
  142
• Pubmed identfication
  • 10964595
• RefSeq identity
  • NM_001618
• Classification
  • Zinc fingers PARP-type
  • Zinc fingers
  • Poly(ADP-ribose) polymerases
• VEGA ID
  OTTHUMG00000037556

Gene info

• Identity
  HGNC:21919
• Gene
  PARP12
• Long gene name
  poly(ADP-ribose) polymerase family member 12
• Synonyms gene
  • ZC3HDC1
• Synonyms gene name
  • zinc finger CCCH-type domain containing 1
• Synonyms
  • FLJ22693
  • PARP-12
  • ZC3H1
  • ARTD12
• GenBank acession
  • AL136766
• Locus
  7q34
• Discovery year
  2003-12-10
• Entrez gene record
  64761
• Pubmed identfication
  • 11230166
  • 12851707
• RefSeq identity
  • NM_022750
• Classification
  • Poly(ADP-ribose) polymerases
  • Zinc fingers CCCH-type
• VEGA ID
  OTTHUMG00000157315

Gene info

• Identity
  HGNC:11941
• Gene
  TNKS
• Long gene name
  tankyrase
• Synonyms gene name
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
• Synonyms
  • TIN1
  • TINF1
  • TNKS1
  • PARP-5a
  • PARP5A
  • pART5
  • ARTD5
• Synonyms name
  • TRF1-interacting ankyrin-related ADP-ribose polymerase 1
• GenBank acession
  • AF082556
• Locus
  8p23.1
• Discovery year
  1999-01-08
• Entrez gene record
  8658
• Pubmed identfication
  • 9822378
  • 10198177
• RefSeq identity
  • NM_003747
• Classification
  • Poly(ADP-ribose) polymerases
  • Sterile alpha motif domain containing
  • Ankyrin repeat domain containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000090481

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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