AZ-5104

• Catalog number
  9441-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
• Description
  AZ-5104 is an active, demethylated metabolite of AZD-9291 (Cat.No.2674). It displays similar overall activity profile with AZD-9291, but is more potent against mutant EGFR forms, while hitting the wild-type EGFR form at a lower concentration thus demonstrating a smaller selectivity margin compared with the parent. Like AZD-9291, AZ-5104 displays potent antitumor activities both in vitro and in vivo.
• CAS Number
  1421373-98-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₃₁N₇O₂
• Molecular Weight
  485.58
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  Apotent EGFR inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  71496460
• PubChem CID Link
• SMILES
  CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC
• InChi
  InChI=1S/C27H31N7O2/c1-6-26(35)30-22-15-23(25(36-5)16-24(22)34(4)14-13-33(2)3)32-27-28-12-11-21(31-27)19-17-29-20-10-8-7-9-18(19)20/h6-12,15-17,29H,1,13-14H2,2-5H3,(H,30,35)(H,28,31,32)
• InChi Key
  IQNVEOMHJHBNHC-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AZ-5104  
• Short name
  AZ-5104
• Alternative name
  AZ-5104

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