Heparanase Antibody

• Catalog number
  bs-1541R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Heparanase Primary Polyclonal Antibody
• Also known as
  Heparanase PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Heparanase
• Specificity
  This is a highly specific antibody against Heparanase.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  140-190/543
• Subcellular location
  Nucleus, Secreted
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Heparanase 50 kDa subunit
• Gene ID number
  10855
• Swiss Prot
  Q9Y251
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  HPA; HPA1; HPR1; HSE1; HPSE1; Heparanase; Endo-glucoronidase; Heparanase-1; HPSE; HEP
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Heparanase  
• Gene symbol
  HPSE2, HPSE
• Short name
  Anti-Heparanase
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Heparanase Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:18374
• Gene
  HPSE2
• Long gene name
  heparanase 2 (inactive)
• Synonyms gene
  • UFS
• Synonyms gene name
  • urofacial syndrome
  • heparanase 2
• Synonyms
  • HPA2
  • HPR2
• GenBank acession
  • AF282885
• Locus
  10q24.2
• Discovery year
  2002-09-02
• Entrez gene record
  60495
• Pubmed identfication
  • 11027606
  • 20560210
  • 9199567
  • 20576607
• RefSeq identity
  • NM_021828
• Classification
  • Heparanases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000018880

Gene info

• Identity
  HGNC:5164
• Gene
  HPSE
• Long gene name
  heparanase
• Synonyms
  • HPA
  • HSE1
  • HPSE1
• GenBank acession
  • AF144325
• Locus
  4q21.23
• Discovery year
  1999-09-28
• Entrez gene record
  10855
• Pubmed identfication
  • 10395325
  • 10395326
• RefSeq identity
  • NM_006665
• Classification
  • Heparanases
• VEGA ID
  OTTHUMG00000130425

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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