Berbamine dihydrochloride

Alternative_name

Berbenine
Description

Berbemine is a naturally occurring alkaloid that displays several biological properties. Berbamine potently suppresses liver cancer cell proliferation and induces cancer cell death by targeting Ca²⁺/calmodulin-dependent protein kinase II (CAMKII). Also acts as a novel inhibitor of NF-kappaB activity with remarkable anti-myeloma efficacy.
CAS Number

6078-17-7
Structure Available

Y
Salt Form

No
Molecular Formula

C₃₇H₄₂Cl₂N₂O₆
Molecular Weight

681.65
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO or EtOH
Handling

Protect from air and moisture
Tag Line

A Ca²⁺/calmodulin-dependent kinase type II inhibitor
Storage Condition

-20°C
Shipping Condition

Gel pack
Shelf Life

24 months
MDL Number

MFCD11982910
PubChem CID

16217067
PubChem CID Link
SMILES

CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC.Cl.Cl
InChi

InChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33;;/h6-11,18-21,28-29,40H,12-17H2,1-5H3;2*1H/t28-,29+;;/m0../s1
InChi Key

USRXDYNDPPUBSG-KKXMJGKMSA-N
Data Sheet Link
MSDS Available

Yes