GSK-J4 hydrochloride

• Catalog number
  2259-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  Ethyl 3-​((6-​(4,​5-​dihydro-​1H-​benzo[d]azepin-​3(2H)-​yl)-​2-​-(pyridin-2- yl)pyrimidin-4-yl)amino)propanoate, monohydrochloride
• Description
  Cell-permeable. An ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (Cat. No. 2260-1, 5) (IC₅₀> 50 μM in vitro. When administered to human primary macrophages, GSK-J4 can reduce lipopolysaccharide (LPS)-induced proinflammatory cytokine production, most notably including that of TNFα (IC₅₀ = 9 µM).
• Structure Available
  Yes
• Peptide sequence
  No
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₇N₅O₂ ∙ HCl
• Molecular Weight
  454
• Cell Permeable
  Yes
• Purity
  ≥95%
• Solubilities
  DMSO
• Handling
  Protect from light and mositure
• Tag Line
  Histone demethylase JMJD3/UTX inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• SMILES
  N/A
• InChi
  N/A
• InChi Key
  N/A
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GSK-J4   hydrochloride  
• Short name
  GSK-J4 hydrochloride
• Alternative name
  GSK-J4 hydrochloride

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