Galectin-3, human recombinant

• Catalog number
  4684-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  IgE-binding protein, MAC2, L-29, CPB-35
• Alternative_names
  IgE-binding protein, MAC2, L-29, CPB-35, 35 kDa lectin, Carbohydrate-binding protein 35, Galactose-specific lectin 3, Galactoside-binding protein, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen
• Description
  A protein involved in cell growth and differentiation, cell cycle, and apoptosis.
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Biological activity
  Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 µg/ml with a peak response obtained at 250 µg/ml.
• Results
  250 µg/ml
• Molecular Weight
  26.0 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered and lyophilized from 0.5X PBS, pH 7.2.
• Reconstitution Instructions
  Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
• Background Information
  Lectins are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galactin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 can function intraCellularly in controlling cell cycle and preventing T-cell apoptosis, and also extraCellularly, in activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Recombinant Galectin-3 is a globular 26.0 kDa protein containing 250 amino acid residues, but no disulfide bonds.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Galectin-3  
• Gene symbol
  LGALS3, LGALS3BP
• Short name
  Galectin-3, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Galectin-3, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:6563
• Gene
  LGALS3
• Long gene name
  galectin 3
• Synonyms gene
  • LGALS2
• Synonyms gene name
  • lectin, galactoside-binding, soluble, 3
• Synonyms
  • MAC-2
  • GALIG
• Synonyms name
  • advanced glycation end-product receptor 3
• GenBank acession
  • M64303
• Locus
  14q22.3
• Discovery year
  1991-09-13
• Entrez gene record
  3958
• Pubmed identfication
  • 2009535
  • 8063692
• RefSeq identity
  • NM_002306
• Classification
  • Receptor ligands
  • Galectins
• VEGA ID
  OTTHUMG00000171030

Gene info

• Identity
  HGNC:6564
• Gene
  LGALS3BP
• Long gene name
  galectin 3 binding protein
• Synonyms gene name
  • lectin, galactoside-binding, soluble, 3 binding protein
• Synonyms
  • MAC-2-BP
  • 90K
  • BTBD17B
  • TANGO10B
  • M2BP
  • gp90
  • CyCAP
• Synonyms name
  • L3 antigen
  • Mac-2-binding protein
  • serum protein 90K
  • transport and golgi organization 10 homolog B (Drosophila)
• GenBank acession
  • L13210
• Locus
  17q25
• Discovery year
  1994-09-30
• Entrez gene record
  3959
• Pubmed identfication
  • 7698018
  • 8034587
  • 8390986
• RefSeq identity
  • NM_005567
• Classification
  • BTB domain containing
  • Scavenger receptor cysteine rich domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000177572

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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