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Also known as
Cytokeratin
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Other names
keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 10; keratin, type I cytoskeletal 10; CK-10; keratin-10; cytokeratin 10; keratin 10; Cytokeratin-10; CK-10; Keratin-10; K10
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Category
Antibodies
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Subcategory
Mnoclonal antibodies
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Gene name
KRT10
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Gene name synonims
KRT14; KRT15; KRT6; KRT19
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Other gene names
KRT10; KRT10; BIE; EHK; K10; KPP; BCIE; CK10; KPP; CK-10; K10
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Clonality
Monoclonal
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Immunoglobulin isotype
IgG1
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Clone
AE-1
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Host organism
Mouse (Mus musculus)
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Species reactivity
Human (Homo sapiens), Monkey, Cow, Dog, Rabbit (Oryctolagus cuniculus), Mouse (Mus musculus), Rat (Rattus norvegicus), Chicken, Turtle.; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivity
This MAb recognizes the 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19) keratins of the acidic (Type I or LMW) subfamily. Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification method
N/A
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Form Appearance
N/A
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Concentration
N/A
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Storage and shipping
Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
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Tested applications
ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistology (IH)