TW-37

• Catalog number
  2789-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
• Description
  TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.  TW-37 inhibits the growth of a broad range of cancer cells (such as breast, prostate, lymphoma, and pancreatic cancer), since it induces S-phase cell cycle arrest with regulation of several important cell cycle related genes, including p27, p57, E2F-1, cdc25A, CDK4, cyclin A, cyclin D1 and cyclin E.
• CAS Number
  877877-35-5
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₃₃H₃₅NO₆S
• Molecular Weight
  573.7
• Cell Permeable
  Y
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A Bcl-2 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD17010275
• PubChem CID
  11455910
• PubChem CID Link
• SMILES
  CC(C)C1=CC=CC=C1CC2=C(C(=C(C(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C)O)O)O
• InChi
  InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38)
• InChi Key
  PQAPVTKIEGUPRN-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  TW-37  
• Gene symbol
  SNORD115-37, IGLV5-37, IGHV3-37, MT-TW, IGKV1-37, IGKV1D-37, RNU6-37P, LIN37, RNVU1-14, NIP7
• Short name
  TW-37
• Alternative name
  TW-37

Gene info

• Identity
  HGNC:33056
• Gene
  SNORD115-37
• Long gene name
  small nucleolar RNA, C/D box 115-37
• Synonyms
  • HBII-52-37
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033811
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003352.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5922
• Gene
  IGLV5-37
• Long gene name
  immunoglobulin lambda variable 5-37
• GenBank acession
  • Z73672
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28783
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151069

Gene info

• Identity
  HGNC:5600
• Gene
  IGHV3-37
• Long gene name
  immunoglobulin heavy variable 3-37 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 3-37
  • immunoglobulin heavy variable 3-37 pseudogene
• GenBank acession
  • M99668
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28430
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152083

Gene info

• Identity
  HGNC:7501
• Gene
  MT-TW
• Long gene name
  mitochondrially encoded tRNA-Trp (UGA/G)
• Synonyms gene
  • MTTW
• Synonyms gene name
  • tRNA tryptophan
  • mitochondrially encoded tRNA tryptophan
• Synonyms
  • trnW
• Locus
  mitochondria
• Discovery year
  1989-10-12
• Entrez gene record
  4578
• Pubmed identfication
  • 7219534
• Classification
  • Mitochondrially encoded transfer RNAs

Gene info

• Identity
  HGNC:5739
• Gene
  IGKV1-37
• Long gene name
  immunoglobulin kappa variable 1-37 (non-functional)
• Synonyms gene name
  • immunoglobulin kappa variable 1-37
• Synonyms
  • IGKV137
  • O14
• GenBank acession
  • X59316
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28931
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151689

Gene info

• Identity
  HGNC:5755
• Gene
  IGKV1D-37
• Long gene name
  immunoglobulin kappa variable 1D-37 (non-functional)
• Synonyms gene name
  • immunoglobulin kappa variable 1D-37
• Synonyms
  • IGKV1D37
  • O4
• GenBank acession
  • X71893
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28894
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000159960

Gene info

• Identity
  HGNC:34281
• Gene
  RNU6-37P
• Long gene name
  RNA, U6 small nuclear 37, pseudogene
• Synonyms gene
  • RNU6-37
• Synonyms gene name
  • RNA, U6 small nuclear 37
• Locus
  1p36.22
• Discovery year
  2008-06-10
• Entrez gene record
  106478920

Gene info

• Identity
  HGNC:33234
• Gene
  LIN37
• Long gene name
  lin-37 DREAM MuvB core complex component
• Synonyms gene name
  • lin-37 homolog (C. elegans)
• Synonyms
  • ZK418.4
  • F25965
  • lin-37
• GenBank acession
  • BC008939
• Locus
  19q13.12
• Discovery year
  2007-05-17
• Entrez gene record
  55957
• Pubmed identfication
  • 21498570
• RefSeq identity
  • NM_019104
• VEGA ID
  OTTHUMG00000182070

Gene info

• Identity
  HGNC:48319
• Gene
  RNVU1-14
• Long gene name
  RNA, variant U1 small nuclear 14
• Synonyms
  • vU1.14
  • RNU1-37
• Locus
  1q21.2
• Discovery year
  2013-04-25
• Entrez gene record
  101954266
• Pubmed identfication
  • 23070852
• RefSeq identity
  • NR_104075
• Classification
  • Variant U1 small nuclear RNAs

Gene info

• Identity
  HGNC:24328
• Gene
  NIP7
• Long gene name
  nucleolar pre-rRNA processing protein NIP7
• Synonyms gene name
  • nuclear import 7 homolog (S. cerevisiae)
• Synonyms
  • CGI-37
  • FLJ10296
  • HSPC031
  • KD93
• GenBank acession
  • AB112439
• Locus
  16q22.1
• Discovery year
  2005-12-01
• Entrez gene record
  51388
• Pubmed identfication
  • 14660641
  • 22195017
  • 20798176
• RefSeq identity
  • NM_016101
• Classification
  • Ribosomal biogenesis factors
• VEGA ID
  OTTHUMG00000137568

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