Recombinant Human M-CSF / CSF-1 Protein 20µg

• Catalog number
  PKSH031969-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  CSF-1;M-CSF;MCSF
• Activity
  Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells.The ED50 for this effect is typically 1.6-6.3 ng/mL.
• Sequence
  Met1-Asn190
• Fusion tag
  NA
• Accession
  NP_757349.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞85 % as determined by SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  18.4 kDa
• AP Mol Mass
  18.4 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4.
• Reconstitution
  Please refer to it for detailed information.
• Background
  Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.
• Product URL
• PDF URL
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  M-CSF   CSF-1   Protein   20µg  
• Gene symbol
  CSF1, CSF2, CSF3, IL3, CPT1B, IRAK3, PGAM2, CYP20A1, USP16, CYB5B
• Short name
  Recombinant M-CSF / CSF-1 Protein 20µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens M-CSF / CSF-1 Protein 20µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:2432
• Gene
  CSF1
• Long gene name
  colony stimulating factor 1
• Synonyms gene name
  • colony stimulating factor 1 (macrophage)
• Synonyms
  • M-CSF
  • MCSF
  • MGC31930
• Synonyms name
  • macrophage colony stimulating factor 1
• GenBank acession
  • BC021117
• Locus
  1p13.3
• Discovery year
  1986-01-01
• Entrez gene record
  1435
• Pubmed identfication
  • 1540160
• RefSeq identity
  • NM_000757
• VEGA ID
  OTTHUMG00000011646

Gene info

• Identity
  HGNC:2434
• Gene
  CSF2
• Long gene name
  colony stimulating factor 2
• Synonyms gene name
  • colony stimulating factor 2 (granulocyte-macrophage)
• Synonyms
  • GM-CSF
  • GMCSF
• Synonyms name
  • sargramostim
  • molgramostim
  • granulocyte-macrophage colony stimulating factor
• GenBank acession
  • M11734
• Locus
  5q31.1
• Discovery year
  2001-06-22
• Entrez gene record
  1437
• Pubmed identfication
  • 3898082
  • 2999978
• RefSeq identity
  • NM_000758
• VEGA ID
  OTTHUMG00000059637

Gene info

• Identity
  HGNC:2438
• Gene
  CSF3
• Long gene name
  colony stimulating factor 3
• Synonyms gene
  • GCSF
  • G-CSF
  • C17orf33
• Synonyms gene name
  • chromosome 17 open reading frame 33
  • colony stimulating factor 3 (granulocyte)
• Synonyms
  • MGC45931
• Synonyms name
  • granulocyte colony stimulating factor
  • pluripoietin
  • filgrastim
  • lenograstim
• Locus
  17q21.1
• Discovery year
  2001-06-22
• Entrez gene record
  1440
• Pubmed identfication
  • 3499671
  • 3501046
• RefSeq identity
  • NM_172220
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000133247

Gene info

• Identity
  HGNC:6011
• Gene
  IL3
• Long gene name
  interleukin 3
• Synonyms gene name
  • interleukin 3 (colony-stimulating factor, multiple)
• Synonyms
  • IL-3
  • MULTI-CSF
  • MCGF
  • MGC79398
  • MGC79399
• Synonyms name
  • multilineage-colony-stimulating factor
  • hematopoietic growth factor
  • P-cell stimulating factor
  • mast-cell growth factor
  • colony-stimulating factor, multiple
• GenBank acession
  • M14743
• Locus
  5q31.1
• Discovery year
  2001-06-22
• Entrez gene record
  3562
• Pubmed identfication
  • 3489530
• RefSeq identity
  • NM_000588
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000059640

Gene info

• Identity
  HGNC:2329
• Gene
  CPT1B
• Long gene name
  carnitine palmitoyltransferase 1B
• Synonyms gene name
  • carnitine palmitoyltransferase 1B (muscle)
• Synonyms
  • M-CPT1
  • CPT1-M
• Synonyms name
  • carnitine O-palmitoyltransferase 1B
• GenBank acession
  • U62733
• Locus
  22q13.33
• Discovery year
  1996-08-14
• Entrez gene record
  1375
• Pubmed identfication
  • 9070950
• RefSeq identity
  • NM_152246
• VEGA ID
  OTTHUMG00000137390

Gene info

• Identity
  HGNC:17020
• Gene
  IRAK3
• Long gene name
  interleukin 1 receptor associated kinase 3
• Synonyms gene name
  • interleukin-1 receptor-associated kinase 3
• Synonyms
  • IRAK-M
• GenBank acession
  • AF113136
• Locus
  12q14.3
• Discovery year
  2002-07-17
• Entrez gene record
  11213
• Pubmed identfication
  • 10383454
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000169002

Gene info

• Identity
  HGNC:8889
• Gene
  PGAM2
• Long gene name
  phosphoglycerate mutase 2
• Synonyms gene name
  • phosphoglycerate mutase 2 (muscle)
• Synonyms
  • PGAM-M
• Locus
  7p13
• Discovery year
  1989-06-30
• Entrez gene record
  5224
• Classification
  • Phosphoglycerate mutases
  • Bisphosphoglycerate phosphatases
• VEGA ID
  OTTHUMG00000155355

Gene info

• Identity
  HGNC:20576
• Gene
  CYP20A1
• Long gene name
  cytochrome P450 family 20 subfamily A member 1
• Synonyms gene name
  • cytochrome P450, family 20, subfamily A, polypeptide 1
• Synonyms
  • CYP-M
• GenBank acession
  • AK021770
• Locus
  2q33.2
• Discovery year
  2003-03-20
• Entrez gene record
  57404
• RefSeq identity
  • NM_020674
• Classification
  • Cytochrome P450 family 20
• VEGA ID
  OTTHUMG00000132854

Gene info

• Identity
  HGNC:12614
• Gene
  USP16
• Long gene name
  ubiquitin specific peptidase 16
• Synonyms gene name
  • ubiquitin specific protease 16
• Synonyms
  • Ubp-M
• GenBank acession
  • AF126736
• Locus
  21q21
• Discovery year
  1999-07-09
• Pubmed identfication
  • 12838346
• Classification
  • Ubiquitin specific peptidases
• VEGA ID
  OTTHUMG00000078802

Gene info

• Identity
  HGNC:24374
• Gene
  CYB5B
• Long gene name
  cytochrome b5 type B
• Synonyms gene name
  • cytochrome b5 type B (outer mitochondrial membrane)
• Synonyms
  • CYB5-M
• Locus
  16q22.1
• Discovery year
  2006-01-30
• Entrez gene record
  80777
• Pubmed identfication
  • 11867265
  • 14733950
• RefSeq identity
  • NM_030579
• VEGA ID
  OTTHUMG00000133020

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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