GSK-J1 sodium salt

Alternative_name

3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate, monosodium salt
Description

A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at higher concentrations (30 μM), has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases.
Structure Available

Yes
Peptide sequence

No
Salt Form

No
Molecular Formula

C₂₂H₂₂N₅O₂ ∙ Na
Molecular Weight

411.43
Cell Permeable

No
Purity

≥95%
Solubilities

DMSO
Handling

Protect from light and mositure
Tag Line

A potent histone demethylase JMJD3/UTX inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
SMILES

N/A
InChi

N/A
InChi Key

N/A
Data Sheet Link
MSDS Available

Yes