Anti-EGFR (Panitumumab), humanized antibody

• Catalog number
  A1050-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  EGFR
• Target Alternative Name
  Vectibix
• Antibody Type
  Monoclonal
• Species Reactivities
  Human
• Immunogen Sequence
  EGFR
• Accession
  AAI18666
• Gene Id
  1956
• Appearance
  Colourless liquid
• Form
  Liquid
• Concentration
  2 mg/ml
• Formulation
  100 ug (2 mg/ml) of antibody in Phosphate buffered saline, pH 7.4.
• Purification
  human IgG2k was expressed in a mouse cell line. IgG was purified from mouse cell culture supernatant by protein A chromatography.
• Application
  Neutralization, ELISA
• Application And Usages
  Neutralization : 1-20μg/ml; ELISA: 1μg/ml
• Description
  Panitumumab is the human monoclonal antibody against epidermal growth factor receptor (EGFR). The EGFR is a member of a subfamily of type I receptor tyrosine kinases, including EGFR (HERl, c-ErbB-l), HER2/neu, HER3, and HER4. EGFR is a transmembrane glycoprotein that is constitutively expressed in many normal epithelial tissues, including the skin and hair follicle. Overexpression of EGFR is also detected in many human cancers, including those of the colon and rectum. Panitumumab binds specifically and selectively to the EGFR, preventing binding of activating ligands, such as the EGF and transforming growth factor-α. This binding results in blockade of the essential downstream signaling pathways that are known to govern apoptosis, proliferation and differentiation of both normal and neoplastic cell types in a wide array of tissues.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  EGFR   Panitumumab   humanized  
• Gene symbol
  EGFR-AS1, EGILA, EGFR, RHBDF1
• Short name
  Anti-EGFR (Panitumumab), humanized antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Human IgG1
• Alternative name
  Antibody toEGFR (Panitumumab), humanized (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217

Gene info

• Identity
  HGNC:40207
• Gene
  EGFR-AS1
• Long gene name
  EGFR antisense RNA 1
• Locus
  7p11.2
• Discovery year
  2012-11-06
• Entrez gene record
  100507500
• Pubmed identfication
  • 26271667
  • 28920960
• RefSeq identity
  • NR_047551
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000156126

Gene info

• Identity
  HGNC:54482
• Gene
  EGILA
• Long gene name
  EGFR interacting lncRNA
• Synonyms
  • Lnc-EGFR
• Locus
  14q11.2
• Discovery year
  2019-09-27
• Pubmed identfication
  • 28541302
• Classification
  • Long non-coding RNAs with non-systematic symbols

Gene info

• Identity
  HGNC:3236
• Gene
  EGFR
• Long gene name
  epidermal growth factor receptor
• Synonyms gene
  • ERBB
• Synonyms gene name
  • epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
• Synonyms
  • ERBB1
  • ERRP
• Synonyms name
  • erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)
  • erb-b2 receptor tyrosine kinase 1
• Locus
  7p11.2
• Discovery year
  1986-01-01
• Entrez gene record
  1956
• Pubmed identfication
  • 1505215
• RefSeq identity
  • NM_005228
• Classification
  • Erb-b2 receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000023661
• Locus Specific Databases
  • LRG_304

Gene info

• Identity
  HGNC:20561
• Gene
  RHBDF1
• Long gene name
  rhomboid 5 homolog 1
• Synonyms gene
  • C16orf8
• Synonyms gene name
  • chromosome 16 open reading frame 8
  • rhomboid family 1 (Drosophila)
  • rhomboid 5 homolog 1 (Drosophila)
• Synonyms
  • EGFR-RS
  • FLJ2235
  • Dist1
  • iRhom1
• GenBank acession
  • BC014425
• Locus
  16p13.3
• Discovery year
  2003-04-07
• Entrez gene record
  64285
• Pubmed identfication
  • 8318735
  • 15965977
• RefSeq identity
  • NM_022450
• Classification
  • Rhomboid family
• VEGA ID
  OTTHUMG00000060719

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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