Decernotinib (VX-509)

Alternative_name

(R,Z)-2-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanimidic acid
Description

Decernotinib (VX-509) is a potent and selective JAK3 inhibitor (Ki = 2 nM). it has been shown to dose dependently reduce proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity.
CAS Number

944842-54-0
Structure Available

Yes
Molecular Formula

C₁₈H₁₉F₃N₆O
Molecular Weight

392.38
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>20 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective JAK3 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

59422203
PubChem CID Link
SMILES

CCC(C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3
InChi

InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1
InChi Key

ASUGUQWIHMTFJL-QGZVFWFLSA-N
Data Sheet Link
MSDS Available

Yes