NKH477

• Catalog number
  9427-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride; Colforsin dapropate hydrochloride, 6-(3-dimethylaminopropionyl)forskolin hydrochloride
• Description
  NKH477 is a water-soluble analog of the adenylyl cyclase activator Forskolin (Cat. No. 1531). Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases. It stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms. NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.
• CAS Number
  138605-00-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₄₃NO₈.HCl
• Molecular Weight
  546.1
• Cell Permeable
  Yes
• Purity
  ≥95%
• Solubilities
  DMSO (>50 mg/ml) or H2O (~20 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  An adenylyl cyclase activator
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00236421
• PubChem CID
  444028
• PubChem CID Link
• SMILES
  CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)OC(=O)CCN(C)C.Cl
• InChi
  InChI=1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
• InChi Key
  VIRRLEDAYYYTOD-YHEOSNBFSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  NKH477  
• Short name
  NKH477
• Alternative name
  NKH477

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