-
Alternative_name
N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride; Colforsin dapropate hydrochloride, 6-(3-dimethylaminopropionyl)forskolin hydrochloride
-
Description
NKH477 is a water-soluble analog of the adenylyl cyclase activator Forskolin (Cat. No. 1531). Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases. It stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms. NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.
-
CAS Number
138605-00-2
-
Structure Available
Yes
-
Salt Form
No
-
Molecular Formula
C₂₇H₄₃NO₈.HCl
-
Molecular Weight
546.1
-
Cell Permeable
Yes
-
Purity
≥95%
-
Solubilities
DMSO (>50 mg/ml) or H2O (~20 mg/ml)
-
Handling
Protect from air and moisture
-
Tag Line
An adenylyl cyclase activator
-
Storage Condition
-20°C
-
Shipping Condition
gel pack
-
Shelf Life
36 months
-
MDL Number
MFCD00236421
-
PubChem CID
444028
-
-
SMILES
CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)OC(=O)CCN(C)C.Cl
-
InChi
InChI=1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
-
InChi Key
VIRRLEDAYYYTOD-YHEOSNBFSA-N
-
-
MSDS Available
Yes