Axin1 Antibody, ALEXA FLUOR 647

• Catalog number
  bs-2439R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  Axin1 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-Axin1 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Axin1
• Specificity
  This is a highly specific antibody against Axin1.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  830-862/862
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Axin1
• Gene ID Number
  8312
• Swiss Prot
  O15169
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  AXIN; PPP1R49; Axin-1; Axis inhibition protein 1; hAxin; AXIN1
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-Axin1 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  Axin1  
• Gene symbol
  AXIN1, CSRNP1
• Short name
  Anti-Axin1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  Axin1 Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies
• Alternative to gene target
  axin 1, AXIN and PPP1R49, AXIN1 and IDBG-7404 and ENSG00000103126 and 8312, R-SMAD binding, nuclei, Axin1 and IDBG-154815 and ENSMUSG00000024182 and 12005, AXIN1 and IDBG-633677 and ENSBTAG00000016577 and 504357

Gene info

• Identity
  HGNC:903
• Gene
  AXIN1
• Long gene name
  axin 1
• Synonyms
  • PPP1R49
• Synonyms name
  • protein phosphatase 1, regulatory subunit 49
• GenBank acession
  • AF009674
• Locus
  16p13.3
• Discovery year
  1998-09-17
• Entrez gene record
  8312
• Pubmed identfication
  • 9230313
• Classification
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000064930

Gene info

• Identity
  HGNC:14300
• Gene
  CSRNP1
• Long gene name
  cysteine and serine rich nuclear protein 1
• Synonyms gene
  • AXUD1
• Synonyms gene name
  • AXIN1 up-regulated 1
  • cysteine-serine-rich nuclear protein 1
• Synonyms
  • URAX1
  • DKFZp566F164
  • FAM130B
  • TAIP-3
• GenBank acession
  • AB053121
• Locus
  3p22.2
• Discovery year
  2001-01-03
• Entrez gene record
  64651
• Pubmed identfication
  • 11526492
  • 17726538
• RefSeq identity
  • NM_033027
• VEGA ID
  OTTHUMG00000131293

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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