Cyclin B1

• Catalog number
  GEN438370
• Price
  Please ask
• Size
  100ug

• Also known as
  Cyclin B1
• Other names
  G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin B1; cyclin B1; N/A
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  CCNB1
• Gene name synonims
  N/A
• Other gene names
  CCNB1; CCNB1; CCNB; CCNB
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1, kappa
• Clone
  V92.1
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Hamster.; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  N/A
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
• Tested applications
  ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB), Immunohistology (IH)

• Gene target
  Cyclin  
• Gene symbol
  CCNB1, CCNB1IP1P3, CCNB1IP1P1
• Short name
  Cyclin B1
• Alternative name
  Anti-Cyclin B1

Gene info

• Identity
  HGNC:1579
• Gene
  CCNB1
• Long gene name
  cyclin B1
• Synonyms gene
  • CCNB
• Synonyms name
  • G2/mitotic-specific cyclin B1
• GenBank acession
  • U22364
• Locus
  5q13.2
• Discovery year
  1991-12-10
• Entrez gene record
  891
• Pubmed identfication
  • 1386342
• RefSeq identity
  • NM_031966
• Classification
  • Cyclins
• VEGA ID
  OTTHUMG00000097817

Gene info

• Identity
  HGNC:37695
• Gene
  CCNB1IP1P3
• Long gene name
  cyclin B1 interacting protein 1 pseudogene 3
• Locus
  Xq21.33
• Discovery year
  2010-01-14
• Entrez gene record
  100128456
• RefSeq identity
  • NG_016614
• VEGA ID
  OTTHUMG00000021978

Gene info

• Identity
  HGNC:37693
• Gene
  CCNB1IP1P1
• Long gene name
  cyclin B1 interacting protein 1 pseudogene 1
• Locus
  1p34.1
• Discovery year
  2010-01-14
• Entrez gene record
  728887
• VEGA ID
  OTTHUMG00000008582

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