Plasma Cell Marker

• Catalog number
  GEN438283
• Price
  Please ask
• Size
  100ug

• Also known as
  Plasma Cell Marker
• Other names
  N/A
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  N/A
• Gene name synonims
  N/A
• Other gene names
  N/A
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG2a
• Clone
  SPM310
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens). Does not react with Rat (Rattus norvegicus).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  N/A
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
• Tested applications
  Immunohistology (IH)
• Description
  For cells, cell lines and tissues in culture till half confluency.

• Gene target
  Plasma  
• Gene symbol
  ATP2B1, ATP2B2, ATP2B4
• Short name
  Plasma
• Technique
  Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA.
• Alternative name
  Anti-Plasma Cell Marker
• Tissue
  cell

Gene info

• Identity
  HGNC:814
• Gene
  ATP2B1
• Long gene name
  ATPase plasma membrane Ca2+ transporting 1
• Synonyms gene name
  • ATPase, Ca++ transporting, plasma membrane 1
• Synonyms
  • PMCA1
• Synonyms name
  • plasma membrane calcium-transporting ATPase 1
• GenBank acession
  • J04027
• Locus
  12q21.33
• Discovery year
  1990-10-05
• Entrez gene record
  490
• Pubmed identfication
  • 1674727
• RefSeq identity
  • NM_001682
• Classification
  • ATPases Ca2+ transporting
• VEGA ID
  OTTHUMG00000169946

Gene info

• Identity
  HGNC:815
• Gene
  ATP2B2
• Long gene name
  ATPase plasma membrane Ca2+ transporting 2
• Synonyms gene name
  • ATPase, Ca++ transporting, plasma membrane 2
• Synonyms
  • PMCA2
• Synonyms name
  • plasma membrane Ca2+ pump 2
  • plasma membrane calcium-transporting ATPase 2
• GenBank acession
  • X63575
• Locus
  3p25.3
• Discovery year
  1992-06-26
• Entrez gene record
  491
• Pubmed identfication
  • 1313367
• RefSeq identity
  • NM_001683
• Classification
  • ATPases Ca2+ transporting
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000128679

Gene info

• Identity
  HGNC:817
• Gene
  ATP2B4
• Long gene name
  ATPase plasma membrane Ca2+ transporting 4
• Synonyms gene
  • ATP2B2
  • MXRA1
• Synonyms gene name
  • matrix-remodelling associated 1
  • ATPase, Ca++ transporting, plasma membrane 4
• Synonyms
  • PMCA4
• Synonyms name
  • plasma membrane calcium-transporting ATPase 4
• GenBank acession
  • M25874
• Locus
  1q32.1
• Discovery year
  1990-10-05
• Entrez gene record
  493
• Pubmed identfication
  • 1674727
• RefSeq identity
  • NM_001001396
• Classification
  • Small nucleolar RNA protein coding host genes
  • ATPases Ca2+ transporting
• VEGA ID
  OTTHUMG00000035906

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