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anti SIRT2 Antibody

anti SIRT2 Antibody is available 3 times from Biovision labs

6138-100 | anti-SIRT2 Antibody size: SIRT2 Antibody | 503.09 USD

Catalog number 6138-100
Supplier Biovision
Price 503.09 USD
Size SIRT2 Antibody
Target of this antibody: SIRT2
Alternative names of antibody target: SIRT2, SIR2, SIR2L, SIR2L2
Background information: The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. This SIRT family of genes is highly conserved from prokaryotes to eukaryotes and is involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. SIRT2, a human homolog of the yeast SIR2 (silent information regulator­2), functions as transcriptional silencing mediator at mating­type loci, telomeres and ribosomal gene clusters. SIRT2 expression increases dramatically during mitosis and is multiply phosphorylated at the G (2)/M transition of the cell cycle. SIRT2 is part of a phosphorylation cascade where it is phosphorylated late in G (2), during M, and into the period of cytokinesis. Inhibition of SIRT2 is reported to rescue alpha­synuclein toxicity and modify inclusion morphology in a cellular model of Parkinson's disease.
Immunogene sequence: C terminal peptide of human SIRT2
Concentration of antibody: N/A
Formulation of this antibody: 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification method: Affinity purified
This antibody has been succesfully tested for use in following methods: Western blot, Immunohistochemistry
Recommended usage: Western blot: 1:500 – 1:2000 dilution, IHC: 1:50 - 1:200 dilution. However, the optimal conditions should be determined individually.
1. Gene info
Identity 10886
Gene SIRT2
Long gene name sirtuin 2
Synonyms gene
  • SIR2L
Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
GenBank acession
  • AF083107
Locus 19q13.2
Discovery year 1998-10-14
Entrez gene record 22933
Pubmed identfication
  • 10393250
  • 10381378
Classification
  • Sirtuins
Havana BLAST/BLAT OTTHUMG00000150480
Product images
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6632-30T | anti-SIRT2 Antibody size: SIRT2 Antibody | 178.63 USD

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6632-100 | anti-SIRT2 Antibody size: SIRT2 Antibody | 384.00 USD

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Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
This antibody reacts with: Human, mouse, rat
Form of antibody: Liquid
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetSIRT2
Short name anti-SIRT2 Antibody
Technique Antibody, anti
Alternative name antibody to-SIRT2 (Antibody to)
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anti-SIRT2 Antibody | Technique alternative | 01012193801
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  • SIRT2
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