lamin A/C Antibody, ALEXA FLUOR 350

• Catalog number
  bs-1841R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  lamin A/C Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-lamin A/C PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  lamin A/C
• Specificity
  This is a highly specific antibody against lamin A/C.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human lamin A/C
• Gene ID Number
  4000
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Nuclear Envelope Marker An important part of the cell nucleus is formed by nuclear lamina. Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. The nuclear lamins comprise a unique subclass of the intermediate filament protein family. They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head, a central rod of a-helices and a carboxyterminal globular domain. Many biochemical and molecular features of lamins have been studied, but their functions remain still largely undetermined. One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus. Besides interactions with the nuclear membrane and other intermediate filaments, lamins interact with the nuclear chromatin. Eukaryotic chromatin is organised into loops, which are attached to the nuclear matrix. This organisation is thought to contribute to compaction of the chromatin and regulation of gene expression. Lamins, as part of the nuclear matrix, may be involved in these processes since chromatin binding sites have been detected in both A- and B-type lamins.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  FPL; FPLD; HGPS; IDC; Lamin A/C; LaminC; LDP1; LGMD1B; LMN 1; LMN C; PRO1; LMNA_HUMAN; Prelamin-A/C; Lamin-A/C; 70 kDa lamin; Renal carcinoma antigenNY-REN-32.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• French translation
  anticorps

• Gene target
  lamin   A/C  
• Gene symbol
  LMNA
• Short name
  Anti-lamin A/C
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  lamin A/C Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6636
• Gene
  LMNA
• Long gene name
  lamin A/C
• Synonyms gene
  • LMN1
  • CMD1A
  • LGMD1B
  • PRO1
  • LMNL1
• Synonyms gene name
  • cardiomyopathy, dilated 1A (autosomal dominant)
  • limb girdle muscular dystrophy 1B (autosomal dominant)
  • progeria 1 (Hutchinson-Gilford type)
  • lamin A/C-like 1
• Synonyms
  • HGPS
  • MADA
• Synonyms name
  • mandibuloacral dysplasia type A
• GenBank acession
  • BC014507
• Locus
  1q22
• Discovery year
  1992-04-09
• Entrez gene record
  4000
• Pubmed identfication
  • 8511676
  • 8838815
  • 12702809
• RefSeq identity
  • NM_170707
• Classification
  • Lamins
• VEGA ID
  OTTHUMG00000013961
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • Leiden Muscular Dystrophy Pages
  • UMD Locus Specific Databases
  • Leiden Muscular Dystrophy pages
  • LRG_254

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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