DASA-58

Alternative_name

3-((4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1,4-diazepan-1-yl)sulfonyl)aniline; ML-203
Description

DASA-58 is a selective activator of pyruvate kinase M2 (PKM2) (AC₅₀ = 38 nM). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated protein. In cancer, the altered glucose metabolism can be influenced by the regulatory properties of PKM2.
CAS Number

1203494-49-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₉H₂₃N₃O₆S
Molecular Weight

453.53
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>50 mg/ml)
Handling

Protect from air and light
Tag Line

A selective pyruvate kinase M2 (PKM2) activator
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

44543605
PubChem CID Link
SMILES

C1CN(CCN(C1)S(=O)(=O)C2=CC=CC(=C2)N)S(=O)(=O)C3=CC4=C(C=C3)OCCO4
InChi

InChI=1S/C19H23N3O6S2/c20-15-3-1-4-16(13-15)29(23,24)21-7-2-8-22(10-9-21)30(25,26)17-5-6-18-19(14-17)28-12-11-27-18/h1,3-6,13-14H,2,7-12,20H2
InChi Key

GMHIOMMKSMSRLY-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:5945
Gene

IGLVV-58
Long gene name

immunoglobulin lambda variable (V)-58 (pseudogene)
Synonyms gene name
- immunoglobulin lambda variable (V)-58
- immunoglobulin lambda variable (V)-58 pseudogene
Synonyms
- IGLV(V)-58
GenBank acession
- D87000
Locus

22q11.22
Discovery year

2000-05-08
Entrez gene record

28758
RefSeq identity
- NG_000002
Classification
- Immunoglobulin lambda locus at 22q11.2
VEGA ID

OTTHUMG00000150893

Identity

HGNC:21396
Gene

ABHD5
Long gene name

abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
Synonyms gene name
- abhydrolase domain containing 5
Synonyms
- CGI-58
- NCIE2
GenBank acession
- AF007132
Locus

3p21.33
Discovery year

2003-06-16
Entrez gene record

51099
Pubmed identfication
RefSeq identity
- NM_016006
Classification
- Abhydrolase domain containing
VEGA ID

OTTHUMG00000133039
Locus Specific Databases
- LRG_1174

Identity

HGNC:17966
Gene

CEP83
Long gene name

centrosomal protein 83
Synonyms gene
- CCDC41
Synonyms gene name
- coiled-coil domain containing 41
- centrosomal protein 83kDa
Synonyms
- NY-REN-58
- NPHP18
GenBank acession
- AF155115
Locus

12q22
Discovery year

2005-12-14
Entrez gene record

51134
Pubmed identfication
- 10508479
- 23348840
RefSeq identity
- NM_016122
VEGA ID

OTTHUMG00000170242

Identity

HGNC:8312
Gene

OR4H6P
Long gene name

olfactory receptor family 4 subfamily H member 6 pseudogene
Synonyms gene
- OR4H9P
- OR4H10P
- OR4H5P
- OR4H11P
- OR4H5
- OR4H7
- OR4H7P
- OR4H2P
- OR4H3P
- OR4H11
- OR4H2
- OR4H3
- OR4H1P
- OR4H4P
- OR4H10
- OR4H4
- OR4H8P
- OR4H8
Synonyms gene name
- olfactory receptor, family 4, subfamily H, member 8 pseudogene
- olfactory receptor, family 4, subfamily H, member 6 pseudogene
Synonyms
- OR15-71
- OR4H6
- OR15-82
- OR4H9
- OR5-39
- OR5-84
- OR4-114
- OR4-115
- OR4-119
- OR15-69
- OR15-80
- OR15-81
- OR14-58
GenBank acession
- U86230
Locus

15q11.2
Discovery year

1999-11-25
Entrez gene record

26322
Pubmed identfication
- 9500546
Classification
- Olfactory receptors, family 4
VEGA ID

OTTHUMG00000172787