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Alternative_name
1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one; (S)-Blebbistatin
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Description
Cell-permeable. The active enantiomer of (±)-Blebbistatin (Cat. No. 2405). A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.0 μM), while weakly inhibiting smooth muscle myosin (IC₅₀ = 80 μM). Through these effects, (-)-blebbistatin reversibly blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells.
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CAS Number
856925-71-8
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₈H₁₆N₂O₂
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Molecular Weight
292.34
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~25 mg/ml)
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Handling
Protect from light and air
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Tag Line
A selective non-muscle myosin II ATPases inhibitor
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Storage Condition
-20 ̊C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD08460907
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PubChem CID
5287792
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SMILES
CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O
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InChi
InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
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InChi Key
LZAXPYOBKSJSEX-GOSISDBHSA-N
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MSDS Available
Yes