CLP-290

• Catalog number
  B1282-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  [5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate
• Description
  CLP-290 is a novel KCC2 (K(+)-Cl(-) cotransporter isoform 2) modulator and prodrug of CLP-257, that is highly selective for KCC2 over related Cl- transporters.
• CAS Number
  1181083-81-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₂₁FN₄O₃S
• Molecular Weight
  404.46
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A novel KCC2 (K(+)-Cl(-) cotransporter isoform 2) modulator and prodrug of CLP-257
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  44188755
• PubChem CID Link
• SMILES
  C1CCN(NC1)C2=NC(=O)C(=CC3=C(C=C(C=C3)F)OC(=O)N4CCCC4)S2
• InChi
  InChI=1S/C19H21FN4O3S/c20-14-6-5-13(15(12-14)27-19(26)23-8-3-4-9-23)11-16-17(25)22-18(28-16)24-10-2-1-7-21-24/h5-6,11-12,21H,1-4,7-10H2/b16-11-
• InChi Key
  DIXMMXNNKLCLOM-WJDWOHSUSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  CLP-290  
• Gene symbol
  COTL1, CALML3, CSRP3, CHID1, PDLIM1, HEXIM1
• Short name
  CLP-290
• Alternative name
  CLP-290

Gene info

• Identity
  HGNC:18304
• Gene
  COTL1
• Long gene name
  coactosin like F-actin binding protein 1
• Synonyms gene name
  • coactosin-like 1 (Dictyostelium)
  • coactosin-like F-actin binding protein 1
• Synonyms
  • CLP
• GenBank acession
  • L54057
• Locus
  16q24.1
• Discovery year
  2002-07-22
• Entrez gene record
  23406
• Pubmed identfication
  • 10051563
  • 9326934
  • 16924104
• RefSeq identity
  • NM_021149
• VEGA ID
  OTTHUMG00000137634

Gene info

• Identity
  HGNC:1452
• Gene
  CALML3
• Long gene name
  calmodulin like 3
• Synonyms gene name
  • calmodulin-like 3
• Synonyms
  • CLP
• GenBank acession
  • X13461
• Locus
  10p15.1
• Discovery year
  1993-07-27
• Entrez gene record
  810
• Pubmed identfication
  • 8476923
• RefSeq identity
  • NM_005185
• Classification
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000017597

Gene info

• Identity
  HGNC:2472
• Gene
  CSRP3
• Long gene name
  cysteine and glycine rich protein 3
• Synonyms
  • CLP
  • MLP
  • CMD1M
• Synonyms name
  • cardiac LIM protein
  • muscle LIM protein
• GenBank acession
  • U20324
• Locus
  11p15.1
• Discovery year
  1999-07-21
• Entrez gene record
  8048
• Pubmed identfication
  • 7490106
• RefSeq identity
  • NM_003476
• Classification
  • LIM domain containing
• VEGA ID
  OTTHUMG00000166100
• Locus Specific Databases
  • LRG_440

Gene info

• Identity
  HGNC:28474
• Gene
  CHID1
• Long gene name
  chitinase domain containing 1
• Synonyms
  • MGC3234
  • FLJ42707
  • SI-CLP
• Synonyms name
  • stabilin-1 interacting chitinase-like protein
• GenBank acession
  • AK124697
• Locus
  11p15.5
• Discovery year
  2005-10-27
• Entrez gene record
  66005
• RefSeq identity
  • NM_023947
• Classification
  • Chitinases
• VEGA ID
  OTTHUMG00000133314

Gene info

• Identity
  HGNC:2067
• Gene
  PDLIM1
• Long gene name
  PDZ and LIM domain 1
• Synonyms gene
  • CLIM1
• Synonyms gene name
  • PDZ and LIM domain 1 (elfin)
• Synonyms
  • CLP-36
  • hCLIM1
  • CLP36
• Synonyms name
  • carboxyl terminal LIM domain protein 1
  • elfin
• GenBank acession
  • U90878
• Locus
  10q23.33
• Discovery year
  1998-01-21
• Entrez gene record
  9124
• Pubmed identfication
  • 10861853
• Classification
  • LIM domain containing
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000018810

Gene info

• Identity
  HGNC:24953
• Gene
  HEXIM1
• Long gene name
  HEXIM P-TEFb complex subunit 1
• Synonyms gene name
  • hexamethylene bisacetamide inducible 1
• Synonyms
  • CLP-1
  • HIS1
  • MAQ1
  • EDG1
• GenBank acession
  • AB021179
• Locus
  17q21.31
• Discovery year
  2005-06-27
• Entrez gene record
  10614
• Pubmed identfication
  • 12119119
  • 12832472
• RefSeq identity
  • NM_006460
• Classification
  • P-TEFb complex subunits
• VEGA ID
  OTTHUMG00000180112

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