Recombinant Mouse ACVR2A / ActrIIa Protein (His & Fc tag) 200µg

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• Catalog number
  PKSM040585-200µg
• Price:

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• Size
  200µg

# #

• Activity
  Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 20-60 ng/mL in the presence of 10 ng/mL recombinant Activin A.
• Synonym
  ActrIIa;Acvr2;TactrII
• Sequence
  Met 1-Pro 134
• Fusion tag
  C-His & Fc
• Accession
  NP_031422.3
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 97 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  41.4 kDa
• AP Mol Mass
  55-65 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

#

• Gene target
  ACVR2A   ActrIIa   Protein   His   tag   200µg  
• Gene symbol
  ACVR2A
• Short name
  Recombinant Mouse ACVR2A / ActrIIa Protein (His & Fc tag) 200µg
• Technique
  Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse ACVR2A / ActrIIa Protein (histidine & fragment c detection labelled) 200µg
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:173
• Gene
  ACVR2A
• Long gene name
  activin A receptor type 2A
• Synonyms gene
  • ACVR2
• Synonyms gene name
  • activin A receptor, type II
  • activin A receptor, type IIA
• Synonyms
  • ACTRII
• Locus
  2q22.3-q23.1
• Discovery year
  1993-09-17
• Entrez gene record
  92
• Pubmed identfication
  • 1314589
  • 10702675
• RefSeq identity
  • NM_001616
• Classification
  • Type 2 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000150603

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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