Ponatinib

• Catalog number
  2712-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide; AP24534
• Description
  Ponatinib is a multi-targeted tyrosine kinase inhibitor that is active against T315I and other BCR-Abl mutants.  It inhibits all tested BCR-Abl mutants in cellular and biochemical assays, suppresses BCR-Abl(T315I)-driven tumor growth in mice, and completely abrogates resistance in cell-based mutagenesis screens.
• CAS Number
  943319-70-8
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₉H₂₇F₃N₆O
• Molecular Weight
  532.56
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~50 mg/ml) or EtOH (~ 25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent multi-kinase and pan-BCR-Abl inhibitor.
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD17215203
• PubChem CID
  24826799
• PubChem CID Link
• SMILES
  CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
• InChi
  InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
• InChi Key
  PHXJVRSECIGDHY-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Ponatinib  
• Short name
  Ponatinib
• Alternative name
  Ponatinib

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