AT-13387

• Catalog number
  B1961-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone; Onalespib
• Description
  AT-13387 is a synthetic, orally bioavailable and small-molecule inhibitor of heat shock protein 90 (Hsp90) with IC₅₀ value of 18 nM in A375 cells. Hsp90 acts as a “molecular chaperone” stabilizing and preventing the breakdown of key cancer-forming (oncogenic) proteins.
• CAS Number
  912999-49-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₃₁N₃O₃
• Molecular Weight
  409.5
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent heat shock protein 90 (Hsp90) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  11955716
• PubChem CID Link
• SMILES
  CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O
• InChi
  InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3
• InChi Key
  IFRGXKKQHBVPCQ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AT-13387  
• Gene symbol
  NBN, GNPAT, SLC33A1
• Short name
  AT-13387
• Alternative name
  AT-13387

Gene info

• Identity
  HGNC:7652
• Gene
  NBN
• Long gene name
  nibrin
• Synonyms gene
  • NBS
  • NBS1
• Synonyms gene name
  • Nijmegen breakage syndrome 1 (nibrin)
• Synonyms
  • ATV
  • AT-V2
  • AT-V1
• GenBank acession
  • AF058696
• Locus
  8q21.3
• Discovery year
  1997-11-28
• Entrez gene record
  4683
• Pubmed identfication
  • 9590181
  • 9590180
• RefSeq identity
  • NM_001024688
• Classification
  • MRN complex
  • BRCA1 C complex
• VEGA ID
  OTTHUMG00000153546
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_158

Gene info

• Identity
  HGNC:4416
• Gene
  GNPAT
• Long gene name
  glyceronephosphate O-acyltransferase
• Synonyms
  • DHAPAT
  • DAPAT
  • DAP-AT
• Synonyms name
  • glycerone-phosphate O-acyltransferase
  • dihydroxyacetone phosphate acyltransferase
• GenBank acession
  • AF043937
• Locus
  1q42.2
• Discovery year
  1998-10-29
• Entrez gene record
  8443
• Pubmed identfication
  • 9459311
  • 9536089
• VEGA ID
  OTTHUMG00000038024

Gene info

• Identity
  HGNC:95
• Gene
  SLC33A1
• Long gene name
  solute carrier family 33 member 1
• Synonyms gene
  • ACATN
  • SPG42
• Synonyms gene name
  • acetyl-Coenzyme A transporter
  • spastic paraplegia 42 (autosomal dominant)
  • solute carrier family 33 (acetyl-CoA transporter), member 1
• Synonyms
  • AT-1
  • AT1
• GenBank acession
  • D88152
• Locus
  3q25.31
• Discovery year
  1999-02-12
• Entrez gene record
  9197
• Pubmed identfication
  • 9096318
  • 19061983
• RefSeq identity
  • NM_004733
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000158481

Similar products