Calcineurin A Antibody

• Catalog number
  3075-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  Calcineurin A
• Target Alternative Name
  PPP3CA, CCN1, CNA1, CALN, CALNA, CALNA1, PPP2B
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat, hamster, rabbit, bovine
• Immunogen Sequence
  Synthetic peptide corresponding to residues surrounding amino acids 267 of human Calcineurin A
• Accession
  P16298
• Gene Id
  5532
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.2 mg/ml
• Formulation
  100 µg (0.2 mg/ml) affinity purified, rabbit anti-Calcineurin A polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
• Purification
  Affinity purified
• Application
  Western blot, Immunoprecipitation
• Application And Usages
  Western Blotting (1-4 µg/ml) and for immunoprecipitation (10-20 µg/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects a 61 kDa band, corresponding to the expected molecular weight of Calcineurin A on immunoblots. A 32 kDa band can also be detected in human samples, presumably to be the cleavage product of Calcineurin A..
• Description
  Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drμgs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Calcineurin  
• Gene symbol
  PPP3CC, PPP3CB, PPP3CA
• Short name
  Calcineurin A Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Calcineurin A (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9316
• Gene
  PPP3CC
• Long gene name
  protein phosphatase 3 catalytic subunit gamma
• Synonyms gene name
  • protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)
  • protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform
  • protein phosphatase 3, catalytic subunit, gamma isozyme
• Synonyms
  • CALNA3
  • PP2Bgamma
• Synonyms name
  • calcineurin A gamma
  • protein phosphatase 2B, catalytic subunit, gamma isoform
• Locus
  8p21.3
• Discovery year
  1993-01-22
• Entrez gene record
  5533
• Pubmed identfication
  • 1339277
• RefSeq identity
  • NM_005605
• Classification
  • Protein phosphatase catalytic subunits
• VEGA ID
  OTTHUMG00000163802

Gene info

• Identity
  HGNC:9315
• Gene
  PPP3CB
• Long gene name
  protein phosphatase 3 catalytic subunit beta
• Synonyms gene
  • CALNB
• Synonyms gene name
  • protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)
  • protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
  • protein phosphatase 3, catalytic subunit, beta isozyme
• Synonyms
  • CALNA2
  • CNA2
  • PP2Bbeta
• Synonyms name
  • calcineurin A beta
  • protein phosphatase 2B, catalytic subunit, beta isoform
• GenBank acession
  • M29551
• Locus
  10q22.2
• Discovery year
  1992-11-09
• Entrez gene record
  5532
• Pubmed identfication
  • 1659808
  • 2558868
• RefSeq identity
  • NM_021132
• Classification
  • Protein phosphatase catalytic subunits
• VEGA ID
  OTTHUMG00000018472

Gene info

• Identity
  HGNC:9314
• Gene
  PPP3CA
• Long gene name
  protein phosphatase 3 catalytic subunit alpha
• Synonyms gene
  • CALN
  • CALNA
• Synonyms gene name
  • protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
  • protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
  • protein phosphatase 3, catalytic subunit, alpha isozyme
• Synonyms
  • CNA1
  • PPP2B
• Synonyms name
  • calcineurin A alpha
  • protein phosphatase 2B, catalytic subunit, alpha isoform
• Locus
  4q24
• Discovery year
  1990-06-26
• Entrez gene record
  5530
• Pubmed identfication
  • 2848250
  • 1659808
• RefSeq identity
  • NM_000944
• Classification
  • Protein phosphatase catalytic subunits
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133839

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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