G protein beta subunit like Antibody, ALEXA FLUOR 647

• Catalog number
  bs-8161R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  G protein beta subunit like Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-G protein beta subunit like PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  G protein beta subunit like
• Specificity
  This is a highly specific antibody against G protein beta subunit like.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human G protein beta subunit like
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.Tissue specificity:Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  G protein beta subunit like; G protein beta subunit-like; Gable; GBL; GBL protein; LST8_HUMAN; Mammalian lethal with SEC13 protein 8; MGC111011; mLST8; Protein GbetaL; Target of rapamycin complex subunit LST8; TORC subunit LST8.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-G protein beta subunit like exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  protein   beta   subunit   like  
• Gene symbol
  GNB1L, MLST8
• Short name
  Anti-G protein beta subunit like
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  G protein beta subunit like Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4397
• Gene
  GNB1L
• Long gene name
  G protein subunit beta 1 like
• Synonyms gene name
  • guanine nucleotide binding protein (G protein), beta polypeptide 1-like
• Synonyms
  • GY2
  • WDR14
• GenBank acession
  • AF238328
• Locus
  22q11.21
• Discovery year
  2000-06-16
• Entrez gene record
  54584
• Pubmed identfication
  • 11072084
• Classification
  • WD repeat domain containing
• VEGA ID
  OTTHUMG00000150279

Gene info

• Identity
  HGNC:24825
• Gene
  MLST8
• Long gene name
  MTOR associated protein, LST8 homolog
• Synonyms gene name
  • MTOR associated protein, LST8 homolog (S. cerevisiae)
• Synonyms
  • Lst8
  • Pop3
  • GBL
  • GbetaL
• Synonyms name
  • G protein beta subunit like
• Locus
  16p13.3
• Discovery year
  2009-05-29
• Entrez gene record
  64223
• Pubmed identfication
  • 25906254
• RefSeq identity
  • NM_022372
• Classification
  • WD repeat domain containing
  • MTOR complex 1
  • MTOR complex 2
• VEGA ID
  OTTHUMG00000128827

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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