NSC-663284

• Catalog number
  B1809-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
• Description
  NSC-663284 is a potent, selective and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC₅₀ = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). Displays > 20- and > 450-fold selectivity over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC₅₀ = 0.2 - 35 μM).
• CAS Number
  383907-43-5
• Structure Available
  Yes
• Molecular Formula
  C₁₅H₁₆ClN₃O₃
• Molecular Weight
  321.76
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (~15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and selective Cdc25A inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD08276924
• PubChem CID
  379077
• PubChem CID Link
• SMILES
  C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
• InChi
  InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
• InChi Key
  BMKPVDQDJQWBPD-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  NSC-663284  
• Short name
  NSC-663284
• Alternative name
  NSC-663284

Product images

Similar products