LSN-2814617

Alternative_name

LSN2814617,5-[(7S)-3-tert-butyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-3-(4-fluorophenyl)-1,2,4-oxadiazole
Description

LSN-2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). It acts as a potent and selective potentiator of human and rat mGlu₅ receptors in vitro, displaying curve shift ratios of two to three fold in the concentration-response relationship to glutamate or the glutamate receptor agonist, DHPG, with no detectable intrinsic agonist properties.
CAS Number

1313498-08-6
Structure Available

Yes
Molecular Formula

C₁₈H₂₀FN₅O
Molecular Weight

341.39
Cell Permeable

1
Purity

≥98% by HPLC
Solubilities

In DMSO
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A potent and selective positive allosteric modulator at the mGlu5 receptor
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

67300245
PubChem CID Link
SMILES

CC(C)(C)C1=NN=C2N1CCC(C2)C3=NC(=NO3)C4=CC=C(C=C4)F
InChi

InChI=1S/C18H20FN5O/c1-18(2,3)17-22-21-14-10-12(8-9-24(14)17)16-20-15(23-25-16)11-4-6-13(19)7-5-11/h4-7,12H,8-10H2,1-3H3
InChi Key

NPRJTKMKUYJGAL-UHFFFAOYSA-N
Data Sheet Link