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Also known as
Human Immunodeficiency Virus Type-1 p24
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Other names
Gag-Pol; Gag-Pol polyprotein; Gag-Pol; Gag-Pol polyprotein; Gag-Pol Transframe peptide; aspartic peptidase; p66 subunit; integrase; reverse transcriptase p51 subunit; N/A; Pr160Gag-PolCleaved into the following 11 chains:Matrix protein p17; MA; Capsid protein p24; CA; Spacer peptide p2; Nucleocapsid protein p7; NC; Transframe peptide; TF; p6-pol; p6*; Protease (EC:3.4.23.16)Alternative name(s):PR; Retropepsin
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Category
Antibodies
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Subcategory
Mnoclonal antibodies
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Gene name
gag-pol; P04585.; N/A; MA; CA; NC; TF; p6*; IN
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Gene name synonims
gag-pol; P04585.; N/A; MA; CA; NC; TF; p6*; IN
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Other gene names
gag-pol; P04585.; N/A; MA; CA; NC; TF; p6*; IN
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Clonality
Monoclonal
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Immunoglobulin isotype
IgG1, kappa
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Clone
HIV1-24/661
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Host organism
Mouse (Mus musculus)
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Species reactivity
HIV Type 1.; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivity
Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification method
N/A
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Form Appearance
N/A
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Concentration
N/A
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Storage and shipping
Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
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Tested applications
ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF)
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
