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Alternative_name
(S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride; XL-413 hydrochloride
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Description
BMS-863233 is a potent and selective CDC7 (cell division cycle 7 homolog) inhibitor. BMS-863233 binds to and inhibits the activity of CDC7, resulting in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.
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CAS Number
1169562-71-3
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Structure Available
Y
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Salt Form
No
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Molecular Formula
C₁₄H₁₃Cl₂N₃O₂
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Molecular Weight
326.17
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Cell Permeable
Yes
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Purity
>98% by HPLC
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Solubilities
DMSO
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Handling
Protect from air and moisture
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Tag Line
A potent and selective CDC7 inhibitor
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Storage Condition
-20 ̊C
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Shipping Condition
Gel pack
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Shelf Life
36 months
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PubChem CID
57899889
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SMILES
C1CC(NC1)C2=NC(=O)C3=C(N2)C4=C(O3)C=CC(=C4)Cl
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InChi
InChI=1S/C14H12ClN3O2/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9/h3-4,6,9,16H,1-2,5H2,(H,17,18,19)/t9-/m0/s1
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InChi Key
JJWLXRKVUJDJKG-VIFPVBQESA-N
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MSDS Available
Yes
