CCT-129202

• Catalog number
  B1934-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-[4-[6-chloro-2-[4-(dimethylamino)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
• Description
  CCT-129202 is a potent, ATP-competitive inhibitor of Aurora kinases with IC₅₀ values of 42 nM, 198 nM and 227 nM for Aurora A, B and C, respectively. CCT-129202 displays high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines.
• CAS Number
  942947-93-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₅ClN₈OS
• Molecular Weight
  497.02
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 3 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent, ATP-competitive inhibitor of Aurora kinases
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  16202152
• PubChem CID Link
• SMILES
  CN(C)C1=CC=C(C=C1)C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC(=O)NC5=NC=CS5)Cl
• InChi
  InChI=1S/C23H25ClN8OS/c1-30(2)16-5-3-15(4-6-16)21-28-19-20(17(24)13-26-22(19)29-21)32-10-8-31(9-11-32)14-18(33)27-23-25-7-12-34-23/h3-7,12-13H,8-11,14H2,1-2H3,(H,25,27,33)(H,26,28,29)
• InChi Key
  QYKHWEFPFAGNEV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  CCT-129202  
• Gene symbol
  PCYT1B, FLVCR2, TRR-CCT6-2, TRR-CCT4-1, TRR-CCT5-1, TRR-CCT1-1, TRR-CCT8-1, TRR-CCT9-1, TRR-CCT3-1
• Short name
  CCT-129202
• Alternative name
  CCT-129202

Gene info

• Identity
  HGNC:8755
• Gene
  PCYT1B
• Long gene name
  phosphate cytidylyltransferase 1B, choline
• Synonyms gene name
  • phosphate cytidylyltransferase 1, choline, beta isoform
  • phosphate cytidylyltransferase 1, choline, beta
• Synonyms
  • CCT-beta
  • CTB
  • CCTbeta
• Synonyms name
  • CTP:phosphocholine cytidylyltransferase-beta
  • choline-phosphate cytidylyltransferase beta
  • phosphorylcholine transferase beta
• GenBank acession
  • AF052510
• Locus
  Xp22.11
• Discovery year
  1999-05-05
• Entrez gene record
  9468
• Pubmed identfication
  • 9593753
• RefSeq identity
  • NM_004845
• VEGA ID
  OTTHUMG00000021270
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:20105
• Gene
  FLVCR2
• Long gene name
  FLVCR heme transporter 2
• Synonyms gene
  • C14orf58
• Synonyms gene name
  • chromosome 14 open reading frame 58
  • feline leukemia virus subgroup C cellular receptor 2
  • feline leukemia virus subgroup C cellular receptor family member 2
• Synonyms
  • FLJ20371
  • MFSD7C
  • SLC49A2
  • CCT
• GenBank acession
  • AK000378
• Locus
  14q24.3
• Discovery year
  2002-12-18
• Entrez gene record
  55640
• Pubmed identfication
  • 16439531
  • 20206334
• RefSeq identity
  • NM_017791
• Classification
  • Solute carriers
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000171487

Gene info

• Identity
  HGNC:35019
• Gene
  TRR-CCT6-2
• Long gene name
  tRNA-Arg (anticodon CCT) 6-2
• Synonyms gene
  • TRNAR31P
• Synonyms gene name
  • transfer RNA arginine 31 (anticodon CCU) pseudogene
  • transfer RNA-Arg (CCT) 6-2
• Synonyms
  • tRNA-Arg-CCT-6-2
• GenBank acession
  • HG983611
• Locus
  1q21.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189449

Gene info

• Identity
  HGNC:34975
• Gene
  TRR-CCT4-1
• Long gene name
  tRNA-Arg (anticodon CCT) 4-1
• Synonyms gene
  • TRNAR27
• Synonyms gene name
  • transfer RNA arginine 27 (anticodon CCU)
  • transfer RNA-Arg (CCT) 4-1
• Synonyms
  • tRNA-Arg-CCT-4-1
• GenBank acession
  • HG983608
• Locus
  7q34
• Discovery year
  2008-08-29
• Entrez gene record
  100189406
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34833
• Gene
  TRR-CCT5-1
• Long gene name
  tRNA-Arg (anticodon CCT) 5-1
• Synonyms gene
  • TRNAR23
• Synonyms gene name
  • transfer RNA arginine 23 (anticodon CCU)
  • transfer RNA-Arg (CCT) 5-1
• Synonyms
  • tRNA-Arg-CCT-5-1
• GenBank acession
  • HG983609
• Locus
  16p13.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189270
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34638
• Gene
  TRR-CCT1-1
• Long gene name
  tRNA-Arg (anticodon CCT) 1-1
• Synonyms gene
  • TRNAR8
• Synonyms gene name
  • transfer RNA arginine 8 (anticodon CCU)
  • transfer RNA-Arg (CCT) 1-1
• Synonyms
  • tRNA-Arg-CCT-1-1
• GenBank acession
  • HG983605
• Locus
  17q25.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189078
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:35077
• Gene
  TRR-CCT8-1
• Long gene name
  tRNA-Arg (anticodon CCT) 8-1
• Synonyms gene
  • TRNAR32P
• Synonyms gene name
  • transfer RNA arginine 32 (anticodon CCU) pseudogene
  • transfer RNA-Arg (CCT) 8-1
• Synonyms
  • tRNA-Arg-CCT-8-1
• GenBank acession
  • HG983613
• Locus
  1q21.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189502

Gene info

• Identity
  HGNC:35114
• Gene
  TRR-CCT9-1
• Long gene name
  tRNA-Arg (anticodon CCT) 9-1
• Synonyms gene
  • TRNAR34P
• Synonyms gene name
  • transfer RNA arginine 34 (anticodon CCU) pseudogene
  • transfer RNA-Arg (CCT) 9-1
• Synonyms
  • tRNA-Arg-CCT-9-1
• GenBank acession
  • HG983614
• Locus
  11q13.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189537
• Classification
  • Cytoplasmic transfer RNA pseudogenes

Gene info

• Identity
  HGNC:34730
• Gene
  TRR-CCT3-1
• Long gene name
  tRNA-Arg (anticodon CCT) 3-1
• Synonyms gene
  • TRNAR18
• Synonyms gene name
  • transfer RNA arginine 18 (anticodon CCU)
  • transfer RNA-Arg (CCT) 3-1
• Synonyms
  • tRNA-Arg-CCT-3-1
• GenBank acession
  • HG983607
• Locus
  16p13.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189168
• Classification
  • Cytoplasmic transfer RNAs

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