CB-1158

Alternative_name

2-Amino-6-borono-2-(1-(2,4-dichlorobenzyl)piperidin-4-yl)hexanoic acid; INCB001158
Description

CB-1158 (INCB001158) is a potent, and selective inhibitor of human arginase I (IC₅₀ = 98 nM), an immune-mediated anti-tumor agent. Displays potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, etc.
CAS Number

2095732-06-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₁H₂₂BN₃O₅
Molecular Weight

287.12
Cell Permeable

Yes
Purity

≥97% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent, and selective human arginase I inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
SMILES

ClC1=CC(Cl)=CC=C1CN2CCC(C(N)(CCCCB(O)O)C(O)=O)CC2
InChi

InChI=1S/C18H27BCl2N2O4/c20-15-4-3-13(16(21)11-15)12-23-9-5-14(6-10-23)18(22,17(24)25)7-1-2-8-19(26)27/h3-4,11,14,26-27H,1-2,5-10,12,22H2,(H,24,25)
InChi Key

ISYBHIALKUAHGV-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes