Quinidine Sulfate dihydrate

Alternative_name

Conquinine; β-Quinine
Description

Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. It is also a class I antiarrhythmic drug. It is a substrate (0.05 µM in Caco-2 cells) of P-glycoprotein and can also act as an inhibitor at higher concentrations (~2 µM in Caco-2 cells). Quinidine is also an inhibitor of the cytochrome P450 enzymes 2D6/3A4, and can lead to increased blood levels of lidocaine, Beta blockers, opioids, and some anti-depressants.
CAS Number

6591-63-5
Structure Available

Yes
Salt Form

Sulfate
Molecular Formula

(C₂₀H₂₄N₂O₂)2.H₂SO₄.2H₂O
Molecular Weight

782.9
Cell Permeable

No
Purity

≥97% by HPLC
Solubilities

DMSO (~80 mg/ml), 100% EtOH (~50 mg/ml)
Handling

Protect from light and moisture
Tag Line

A P-glycoprotein substrate, Cytochrome P450 inhibitor
Storage Condition

+4°C
Shipping Condition

gel pack
Shelf Life

12 months
MDL Number

MFCD00149346
PubChem CID

16219922
PubChem CID Link
SMILES

COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O
InChi

InChI=1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
InChi Key

ZHNFLHYOFXQIOW-WFTMRWCJSA-N
Data Sheet Link
MSDS Available

Yes