Quinidine Sulfate dihydrate
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Catalog number
2910-1G
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Price
Please ask
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Size
1 g
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Alternative_name
Conquinine; β-Quinine
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Description
Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. It is also a class I antiarrhythmic drug. It is a substrate (0.05 µM in Caco-2 cells) of P-glycoprotein and can also act as an inhibitor at higher concentrations (~2 µM in Caco-2 cells). Quinidine is also an inhibitor of the cytochrome P450 enzymes 2D6/3A4, and can lead to increased blood levels of lidocaine, Beta blockers, opioids, and some anti-depressants.
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CAS Number
6591-63-5
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Structure Available
Yes
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Salt Form
Sulfate
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Molecular Formula
(C₂₀H₂₄N₂O₂)2.H₂SO₄.2H₂O
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Molecular Weight
782.9
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Cell Permeable
No
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Purity
≥97% by HPLC
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Solubilities
DMSO (~80 mg/ml), 100% EtOH (~50 mg/ml)
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Handling
Protect from light and moisture
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Tag Line
A P-glycoprotein substrate, Cytochrome P450 inhibitor
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Storage Condition
+4°C
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Shipping Condition
gel pack
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Shelf Life
12 months
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MDL Number
MFCD00149346
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PubChem CID
16219922
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SMILES
COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O
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InChi
InChI=1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
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InChi Key
ZHNFLHYOFXQIOW-WFTMRWCJSA-N
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MSDS Available
Yes
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