AM-095

Alternative_name

2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid
Description

AM-095 is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibitsLPA-driven chemotaxis of CHO cells overexpressing mouse LPA₁ (IC₅₀ = 778 nM) and human A2058 melanoma cells (IC₅₀ = 233 nM).
CAS Number

1228690-36-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₇H₂₄N₂O₅
Molecular Weight

456.49
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>5 mg/ml)
Handling

Protect from air and light
Tag Line

A potent LPA1 receptor antagonist
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

46213949
PubChem CID Link
SMILES

CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O
InChi

InChI=1S/C27H24N2O5/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31)/t18-/m1/s1
InChi Key

LNDDRUPAICPXIN-GOSISDBHSA-N
Data Sheet Link
MSDS Available

Yes