anti- GNE antibody

• Catalog number
  FNab03544
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
• Immunogen
  glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
• Synonyms
  GLCNE
• Calculated MW
  120 kDa
• Uniprot ID
  Q9Y223
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
• Image1
  Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab03544( GNE Antibody) at dilution of 1:50
• Image4
  Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03544( GNE Antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  GNE  
• Gene symbol
  GNE
• Short name
  anti- GNE antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, DMRV and GLCNE and IBM2 and NM and Uae1, GNE and IDBG-65042 and ENSG00000159921 and 10020, hydrolase activity, Cytoplasm, Gne and IDBG-143173 and ENSMUSG00000028479 and 50798, GNE and IDBG-633656 and ENSBTAG00000001142 and 782201

Gene info

• Identity
  HGNC:23657
• Gene
  GNE
• Long gene name
  glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
• Synonyms gene
  • IBM2
• Synonyms gene name
  • UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
• Synonyms
  • Uae1
• Synonyms name
  • bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
• GenBank acession
  • AF051852
• Locus
  9p13.3
• Discovery year
  2003-11-28
• Entrez gene record
  10020
• Pubmed identfication
  • 9305887
  • 9305888
• RefSeq identity
  • NM_005476
• VEGA ID
  OTTHUMG00000019899
• Locus Specific Databases
  • LRG_1197

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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