HPI-1

Alternative_name

2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
Description

HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC₅₀’s range from 0.2 to 6 µM for various cell-based assays.
CAS Number

599150-20-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₇H₂₉NO₆ · XH₂O
Molecular Weight

463.52
Cell Permeable

Yes
Purity

≥98% by TLC
Solubilities

DMSO (~25 mg/ml) or EtOH (~25 mg/ml)
Handling

Protect from light and air
Tag Line

A potent Hedgehog signaling pathway inhibitor
Storage Condition

-20 ̊C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD17215941
PubChem CID

71311904
PubChem CID Link
SMILES

CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC.O
InChi

InChI=1S/C27H29NO6.H2O/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3;/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3;1H2
InChi Key

BOASXIAGFOONSK-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

HPI-1
Gene symbol

IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1, MIR1289-1, MIR16-1, PIRC1
Short name

HPI-1
Alternative name

HPI-1

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325

Identity

HGNC:5760
Gene

IGKV1OR2-1
Long gene name

immunoglobulin kappa variable 1/OR2-1 (pseudogene)
Synonyms gene
- IGKVPZ1
- IGKV1OR-1
Synonyms gene name
- immunoglobulin kappa variable 1/OR-1
- immunoglobulin kappa variable 1/OR-1 pseudogene
- immunoglobulin kappa variable 1/OR-1 (pseudogene)
Synonyms
- IGKV1/OR-1
- IGKV1/OR2-1
GenBank acession
- Z12367
Locus

2p11.1
Discovery year

2000-04-18
Entrez gene record

3531
Pubmed identfication
- 2853098
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000155081