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Alternative_name
3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one; Semaxinib
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Description
SU-5416 is a potent tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR-2; Flk-1/KDR). In addition to inhibiting VEGFR-2 (IC₅₀ = 1 μM), SU-5416 also inhibits PDGFR (IC₅₀ = 20 μM), c-Kit (IC₅₀ = 30 nM), RET (IC₅₀ = 170 nM), Flt-3 (IC₅₀ = 160 nM), ABL (IC₅₀ = 11 μM), and ALK (IC₅₀ = 1.2 μM).SU 5416 does not inhibit epidermal growth factor (EGFR) or fibroblast growth factor receptor (FGFR) tyrosine kinases (IC₅₀ > 100 μM). Acts as a suppressor of tumor vascularization, preventing the growth of multiple tumor types.
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CAS Number
204005-46-9
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Structure Available
Yes
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Molecular Formula
C₁₅H₁₄N₂O
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Molecular Weight
238.28
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (>20 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent VEGFR kinase inhibitor
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Storage Condition
-20°C
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Shipping Condition
Gel pack
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Shelf Life
36 months
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MDL Number
MFCD01940922
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PubChem CID
5329098
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SMILES
CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
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InChi
InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
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InChi Key
WUWDLXZGHZSWQZ-WQLSENKSSA-N
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MSDS Available
Yes
