BMS-299897
-
Catalog number9606-25
-
PricePlease ask
-
Size25 mg
-
-
Alternative_name(R)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)butanoic acid
-
DescriptionBMS-299897 is a potent, brain-permeant γ-secretase inhibitor (IC₅₀ = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC₅₀ values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Displays no Notch toxicity.
-
CAS Number290315-45-6
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₂₄H₂₁ClF₃NO₄S
-
Molecular Weight511.94
-
Cell PermeableYes
-
Purity≥98% by HPLC
-
SolubilitiesDMSO (>40 mg/ml)
-
HandlingProtect from air and light
-
Tag LineA potent, brain-permeant γ-secretase inhibitor
-
Storage Condition-20°C
-
Shipping Conditiongel pack
-
Shelf Life36 months
-
MDL NumberMFCD12963627
-
PubChem CID11249248
-
SMILESCC(C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
-
InChiInChI=1S/C24H21ClF3NO4S/c1-15(21-11-7-18(26)13-16(21)3-2-4-24(30)31)29(23-14-19(27)8-12-22(23)28)34(32,33)20-9-5-17(25)6-10-20/h5-15H,2-4H2,1H3,(H,30,31)/t15-/m1/s1
-
InChi KeyIZAOBRWCUGOKNH-OAHLLOKOSA-N
-
MSDS AvailableYes
-
Gene target
-
Short nameBMS-299897
-
Alternative nameBMS-299897
-