BMS-299897

• Catalog number
  9606-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (R)-4-(2-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)butanoic acid
• Description
  BMS-299897 is a potent, brain-permeant γ-secretase inhibitor (IC₅₀ = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC₅₀ values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Displays no Notch toxicity.
• CAS Number
  290315-45-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₁ClF₃NO₄S
• Molecular Weight
  511.94
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>40 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent, brain-permeant γ-secretase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD12963627
• PubChem CID
  11249248
• PubChem CID Link
• SMILES
  CC(C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
• InChi
  InChI=1S/C24H21ClF3NO4S/c1-15(21-11-7-18(26)13-16(21)3-2-4-24(30)31)29(23-14-19(27)8-12-22(23)28)34(32,33)20-9-5-17(25)6-10-20/h5-15H,2-4H2,1H3,(H,30,31)/t15-/m1/s1
• InChi Key
  IZAOBRWCUGOKNH-OAHLLOKOSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BMS-299897  
• Short name
  BMS-299897
• Alternative name
  BMS-299897

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