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Alternative_name
[1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Ametycine
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Description
Mitomycin C is an antitumor antibiotic isolated from Streptomyces sp. Mitomycin is activated by reduction in vivo generating oxygen radicals which produce crosslinks in DNA by alkylaion. This mechanism ultimately inhibits DNA synthesis which has a bacteriostatic effect. Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.
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CAS Number
50-07-7
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Structure Available
Y
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Salt Form
No
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Molecular Formula
C₁₅H₁₈N₄O₅
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Molecular Weight
334.33
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Cell Permeable
No
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Purity
Potency: ≥970 µg/mg
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Solubilities
DMSO (~15 mg/ml) or H₂O (~0.5 mg/ml)
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Handling
Protect from air and light
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Tag Line
An antitumor antibiotic
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Storage Condition
+4°C
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Shipping Condition
Gel pack
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Shelf Life
36 months
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MDL Number
MFCD00078109
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PubChem CID
5746
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SMILES
CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
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InChi
InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
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InChi Key
NWIBSHFKIJFRCO-WUDYKRTCSA-N
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MSDS Available
Yes