PXD101

• Catalog number
  2480-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide; Belinostat
• Description
  A potent histone deacetylase (HDAC) activity inhibitor. It inhibits HDAC activity in HeLa cell extracts with an IC₅₀ of 27 nM. Belinostat significantly increases acetylation of histones H3 and H4 and potently inhibits the growth of prostate cancer cell lines (IC₅₀ range from 0.5 to 2.5 µM) with cytotoxic activity preferentially against tumor cells.
• CAS Number
  414864-00-9
• Structure Available
  Yes
• Molecular Formula
  C₁₅H₁₄N₂O₄S
• Molecular Weight
  318.35
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent histone deacetylase (HDAC) activity inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  6918638
• PubChem CID Link
• SMILES
  C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO
• InChi
  InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
• InChi Key
  NCNRHFGMJRPRSK-MDZDMXLPSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  PXD101  
• Short name
  PXD101
• Alternative name
  PXD101

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